OJO TUNDE OLUWAFEMI

Medicine

At the Medicine department office

Appointment on Visitation important

Topic: Clinical Evolution Of Respiratory Outcomes In Adult TB Patients

Description:

Clinical evolution of respiratory outcomes in Adult TB patients.

Nigeria ranked sixth among the 30 high TB burden countries globally and 1st in Africa. The incidence of post-TB lung disease in Lagos is 6.1%.
Justification
There are a few data on estimates of the frequency of respiratory outcomes on medium and long term after PTB treatment completion in West Africa. This study will help to identify patients at risk of adverse respiratory outcomes that will benefit from appropriate post-TB care.
Research question
What are the respiratory outcomes in adult pulmonary TB patients on DOTS treatment at selected TB treatment centres in Lagos, Nigeria?
Hypothesis
There is no significant adverse respiratory outcome in Adult PTB patients enrolled in DOTS treatment program
Aims

To assess the frequency of respiratory symptoms in TB patients at treatment completion, and 6 months post treatment
Methods
Design-Prospective cohort study
Site- DOTS centers in Ikeja local government,Lagos                                  
Population- Drug susceptible TB patients on programmatic Treatment.
Inclusion criteria
Patient from 15years and above on TB treatment, Patients enrolled at any Ikeja DOTS center and Patient with baseline CXR
Exclusion-
Patient with active TB and concomittant acute respiratory infections, Patients that do not grant consent and TB Patients not on programmatic treatment
Sample size- 220 based on incidence rate of 6.1%, assumed relative risk of 3, confidence of 95% and desired power of 0.8
Sampling method –simple random sampling
Exposure -TB infection- (Pulmonary tuberculosis)
Outcomes
Presence of Cough, shortness of breath, wheeze, hemoptysis and sputum expectoration
FEV1, FVC, FEV1/FVC, PEF
Baseline oxygen saturation
Distance covered during six minutes walk
Data collection
Use of profoma to obtain socio-demographic  and respiratory symptoms using IMPALA/St Georges questionnaire  at completion of treatment, and 6 months post treatment.
CRX
Spirometry data
Six minutes walk test

#	Certificate	School	Year
1.	Ph.D (CLINICAL SCIENCES)	LAGOS STATE UNIVERSITY	2027

Chronic Obstructive Pulmonary Disease awareness in the adult population of seven African cities: A RACE Africa study

Introduction:

The burden of chronic obstructive pulmonary disease (COPD) is increasing in sub-Saharan Africa (SSA). Low COPD awareness contributes to under diagnosis, low policy prioritisation and poor outcomes. The level of COPD awareness across Africa is not well described.
Aim:

To evaluate COPD awareness and knowledge of its symptoms and risk factors among adults in the seven African cities participating in the Raising COPD Awareness in Africa (RACE Africa) project.
Methods:

A cross-sectional community-based survey was conducted in Nigeria (Lagos, Port Harcourt, Katsina), Ethiopia (Addis Ababa), Cameroon (Douala), Rwanda (Kigali), and Burkina Faso (Ouagadougou). A structured questionnaire was used to assess the awareness of COPD, asthma and HIV respectively, including awareness of their risk factors and symptoms. We used logistic regression to explore the factors associated with COPD awareness. Following the survey, we distributed educational materials in the participating communities and more broadly using social media.
Results: There were 7,327 participants (median age 35 years; 52.3% male) and 26.2% had heard of COPD, with large variation across sites. Awareness of tobacco smoking as a risk factor was reported in 7.3%, while 58.9% did not know any cause. Only 6.6% and 5.6% recognized cough and breathlessness, respectively, as COPD symptoms. In contrast, awareness of asthma and HIV exceeded 90%. Tertiary education and previous COPD diagnosis were independently associated with COPD awareness (AOR = 1.476, 95% CI: 1.196–1.822 and 19.91 (10.52–37.69 respectively).
Conclusion:

COPD awareness in Africa is low compared to other chronic diseases such as asthma and HIV. These findings highlight the urgent need for large-scale, context-specific education to improve COPD literacy and guide policy prioritization.
Key-words: COPD, Awareness, Risk factors, Africa, Community survey

OJO OLUWAFEMI is a Associate Professor / Reader at the Department of Medicine

OJO has a Ph.D in CLINICAL SCIENCES from LAGOS STATE UNIVERSITY