SALAMI WASIU OLAWALE

Meet SALAMI WASIU OLAWALE, an Academic Staff of Lagos State University.

Specialization

Microbiology Medical Microbiology

Designation

Graduate Assistant

Department

Microbiology

Office

At the Microbiology department office

Visiting Hour

Appointment on Visitation important

Research Interest

Topic: ESKAPE Pathogens In Relation To One Health Approach

Description: The ESKAPE pathogens are a major concern in the One Health framework, which recognizes the interconnectedness of human health, animal health, and environmental health.One Health Implications of ESKAPE Pathogens:Human Health: The ESKAPE pathogens are leading causes of healthcare-associated infections HAIs and can result in serious, life-threatening illnesses in humans. The increasing antibiotic resistance of these pathogens makes them difficult to treat, leading to higher morbidity, mortality, and healthcare costs.Animal Health: Some ESKAPE pathogens, such as Staphylococcus aureus, can also infect animals, including livestock and companion animals. Antibiotic-resistant strains of these pathogens can be transmitted between animals and humans, further exacerbating the problem. The use of antibiotics in animal agriculture can contribute to the development and spread of antibiotic-resistant ESKAPE pathogens.Environmental Health: The ESKAPE pathogens can be found in various environmental reservoirs, such as water, soil, and surfaces, particularly in healthcare settings and areas with poor sanitation. The release of these pathogens and antibiotic-resistant genes into the environment can contribute to the further development and spread of antibiotic resistance. Environmental contamination with ESKAPE pathogens can lead to exposure and infection in both humans and animals.Addressing the ESKAPE Pathogens through a One Health Approach includes:Implementing comprehensive infection control measures in healthcare settings, including proper hand hygiene, environmental cleaning, and antibiotic stewardship.Improving biosecurity and biosafety practices in animal agriculture to minimize the transmission of ESKAPE pathogens between animals and humans.Enhancing environmental surveillance and remediation efforts to identify and mitigate sources of ESKAPE pathogen contamination.Promoting collaborative research and data-sharing among human health, animal health, and environmental health professionals to better understand the epidemiology and transmission of ESKAPE pathogens.Developing new antimicrobial agents and alternative treatment strategies to combat the growing threat of antibiotic-resistant ESKAPE pathogens

Qualifications

# Certificate SchoolYear
1. M.Sc (Microbiology) Lagos State University 2024

Current Research

Detection of Carbapenemase and Extended Spectrum Beta Lactamases ESBL Producing Enterococcus Species Isolated from Different Sources in Lagos, Nigeria

Research Details

Enterococcus, a gram-positive bacterium found in the human gut, poses significant health risks due to its widespread presence in humans, animals, and the environment. This study aims to investigate the presence of carbapenemase and ESBL production, antimicrobial resistance and virulence genes in Enterococcus spp. from diverse sources in Lagos. Five hundred samples were collected from clinical n=350 , environmental n=50 and animal n=100 sources between November 2023 and February 2024. The samples were processed and Enterococcus isolates were identified by standard methods. The isolates were subjected to antimicrobial susceptibility tests AST and qPCR methods with specific primers for the detection of virulence and resistance genes. The overall prevalence of Enterococcus isolates was 4.6% 23/500 across the three sources with a source prevalence of 24% 12/50 , 5% 5/100 and 1.7% 6/350 for environmental, animal and clinical samples respectively. The result of AST revealed that 100% of Enterococcus isolates were resistant to ciprofloxacin, colistin, cefoxitin, imipenem, vancomycin, ceftazidime, and ampicillin. Six distinct resistance profiles were recorded with AMP-CO-TGC-CIP-TS-VA-CHL-AUG-CAZ-CPM-MEM-FOX-IMI being the most frequent pattern recorded. Interestingly, 39.1 % 9/23 ESBL-producing E. faecalis strains carried gelE virulence gene maker in both clinical and environmental isolates and of which two strains were isolated from cases of bacteremia exhibited coexistence genes markers harbouring blakpc and oxa-48, and blaTEM and blashv. Conclusions: The emergence of antibiotic-resistant Enterococcus strains in Lagos emphasizes the need for a One Health approach to mitigate the spread and molecular studies for a better understanding of transmission dynamics.

Biography

SALAMI WASIU is a Graduate Assistant at the Department of Microbiology

SALAMI has a M.Sc in Microbiology from Lagos State University

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